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calcium sparks
Calcium (Ca2+) sparks are intracellular Ca2+ release events that are important in excitation-contraction coupling. In cardiac muscle cells, a Ca2+ spark arises from the activation of a cluster of ryanodine receptors, which causes Ca2+ to be released from an intracellular organelle, the sarcoplasmic reticulum. Near synchronous activation of ~ 104 Ca2+ sparks produces a cell-wide Ca2+ transient that then activates the myofilaments to cause muscle contraction. Ca2+ sparks are important in physiology as they demonstrate how Ca2+ can be spatio-temporally compartmentalized to control signalling processes at a sub-cellular level. This is now known as "local control" and is key to the production of graded Ca2+ release.
==Activation==
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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